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Senior People Operations Manager - Payroll & Systems

ladders • United States
Full Remote
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Own core people operations infrastructure with a strong emphasis on payroll, HR systems, benefits administration, and compliance across multiple jurisdictions. Manage US and UK payroll end-to-end, HRIS architecture, benefits, leave, policies, and people infrastructure for new entities. Requires 12+ years in HR operations/payroll or 8+ years with a relevant master's degree, plus 5+ years of multi-jurisdiction payroll ownership including California.

Key Highlights
Remote Senior People Ops Manager role focused on payroll, HR systems, benefits, and compliance
Owns US and UK payroll end-to-end across multiple jurisdictions
Oversees HRIS architecture, data integrity, and vendor relationships
Builds people operations infrastructure for new entities and locations
Compensation is $165,000 – $175,000 annually
Key Responsibilities
Own and manage US and UK payroll end-to-end, ensuring accuracy and compliance
Administer benefits, retirement plans, and leave management
Oversee HRIS architecture, data integrity, and vendor relationships
Develop and maintain compliant policies across jurisdictions
Coordinate immigration and compensation processes for new entities
Establish people infrastructure for new entities and manage wind-down processes
Document processes and create controls for payroll and compliance
Technical Skills Required
HRIS
Benefits & Perks
Opportunity to build systems for frontier science and collaborate with top experts
Up to a 6% 401k match for future financial security
Comprehensive medical, dental, and vision insurance, mostly covered for dependents
Company-paid life and disability insurance, with supplemental options
19 holidays, including a mandatory week off at year-end
3 weeks PTO with increases based on tenure, plus separate sick and parental leave
Generous fertility benefits and childcare reimbursement
Education and professional development support
Wellness allowance for fitness activities
Quarterly team retreats and opportunities for in-person meetings

Job Description

For our client, we are seeking a Senior People Ops Manager - Payroll & Systems to join the team of a leader in the Pharmaceuticals & Biotech space.

This role will own core people operations infrastructure with a strong emphasis on payroll, HR systems, benefits administration, and compliance across multiple jurisdictions. You will partner closely with internal stakeholders to build scalable processes, strengthen data governance, and support the people operations needs of new entities and locations. The position also plays a key role in policy development, operational controls, and the administration of complex employee programs in a fast-moving, research-driven environment.

Location: Remote

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