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Principal / Senior Scientist, LNP Discovery & Machine Learning

lazarys • United State
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Lead the discovery and optimization of proprietary LNP formulations for systemic mRNA delivery with a focus on extrahepatic expression. Combine hands-on formulation science with quantitative modeling to design campaigns and build predictive models using Python. Requires a PhD in a relevant scientific field and deep experience in nanoparticle systems and machine learning application.

Key Highlights
Lead LNP discovery for systemic mRNA programs focusing on lung and tumor tissue expression
Integrate formulation science with Bayesian optimization and active learning to inform experimental design
Supervise a Senior Research Associate and report directly to the CSO
Key Responsibilities
Design and execute LNP formulation campaigns across various lipids, compositions, and mixing conditions.
Develop formulations for systemic mRNA delivery emphasizing extrahepatic expression, tolerability, and manufacturability.
Establish and maintain characterization methods for particle size, PDI, RNA encapsulation, and stability.
Develop cell-based screens across tumor and normal-cell models to evaluate productive delivery.
Collaborate with in vivo pharmacology to correlate in vitro performance with biodistribution and tissue expression.
Develop predictive models for formulation data using Python and apply active learning or Bayesian optimization.
Supervise and develop the Senior Research Associate supporting formulation and automation.
Technical Skills Required
LNP Formulation Python Machine Learning
Benefits & Perks
Base salary: 165,000–195,000
Equity: 0.60–1.10%
$500+ monthly wellness budget
100% covered base medical, dental, and vision insurance
HSA, FSA, and 401(k) plans
Visa sponsorship (O-1, H-1B, J-1, TN)
Team dinners, events, and offsites
Nice to Have
Extrahepatic delivery experience
Lung-targeted LNPs
Lipid chemistry
Primary-cell screening
Automated formulation
Endosomal escape assays
High-content imaging
IVIVC/IVIVE
Process development
Formulation scale-up

Job Description

(Principal / Senior) Scientist, LNP Discovery & Machine Learning

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Somerville, Massachusetts · Full Time · Onsite

Base salary: 165,000–195,000 · Equity: 0.60–1.10%

Lazarys is hiring a Principal or Senior Scientist to lead LNP discovery for our systemic mRNA programs.

You will develop and optimize proprietary LNP formulations for systemic delivery, with an initial focus on extrahepatic expression, including the lung and tumor tissue. This role combines formulation science with quantitative modeling: you will design formulation campaigns, generate high-quality experimental datasets, build predictive models, and use those models to inform subsequent rounds of testing.

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